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2008 Missouri Tigers Schedule
| Date | Time (ET) | Opponent | Result | Record |
| 08/30/2008 | 08:30 PM | Illinois | W, 52-42 | 1-0-0 |
| 09/06/2008 | 07:00 PM | SE Missouri St | W, 52-3 | 2-0-0 |
| 09/13/2008 | 12:30 PM | Nevada | W, 69-17 | 3-0-0 |
| 09/20/2008 | 02:00 PM | Buffalo | W, 42-21 | 4-0-0 |
| 10/04/2008 | 09:00 PM | at Nebraska | W, 52-17 | 5-0-0 |
| 10/11/2008 | 08:00 PM | Oklahoma State | L, 28-23 | 5-1-0 |
| 10/18/2008 | 08:00 PM | at Texas | L, 56-31 | 5-2-0 |
| 10/25/2008 | 06:30 PM | Colorado | W, 58-0 | 6-2-0 |
| 11/01/2008 | 03:00 PM | at Baylor | W, 31-28 | 7-2-0 |
| 11/08/2008 | 07:00 PM | Kansas State | W, 41-24 | 8-2-0 |
| 11/15/2008 | 06:30 PM | at Iowa State | W, 52-20 | 9-2-0 |
| 11/29/2008 | 12:30 PM | Kansas | L, 40-37 | 9-3-0 |
| 12/06/2008 | 08:00 PM | at Oklahoma | L, 62-21 | 9-4-0 |
| 12/29/2008 | 08:00 PM | at Northwestern | W, 30-23 | 10-4-0 |
