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2008 North Texas Mean Green Schedule
| Date | Time (ET) | Opponent | Result | Record |
| 08/30/2008 | 07:05 PM | at Kansas State | L, 45-6 | 0-1-0 |
| 09/06/2008 | 07:00 PM | Tulsa | L, 56-26 | 0-2-0 |
| 09/13/2008 | 08:00 PM | at L-S-U | L, 41-3 | 0-3-0 |
| 09/27/2008 | 05:00 PM | at Rice | L, 77-20 | 0-4-0 |
| 10/04/2008 | 07:00 PM | Florida Intl | L, 42-10 | 0-5-0 |
| 10/11/2008 | 07:00 PM | UL Lafayette | L, 59-30 | 0-6-0 |
| 10/18/2008 | 07:00 PM | at UL-Monroe | L, 35-23 | 0-7-0 |
| 10/25/2008 | 07:00 PM | Troy | L, 45-17 | 0-8-0 |
| 11/01/2008 | 04:30 PM | at Western Ky | W, 51-40 | 1-8-0 |
| 11/08/2008 | 04:00 PM | at Fla Atlantic | L, 46-13 | 1-9-0 |
| 11/22/2008 | 03:30 PM | at Middle Tennessee | L, 52-13 | 1-10-0 |
| 11/29/2008 | 02:00 PM | Arkansas State | L, 33-28 | 1-11-0 |
