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2008 Southern Illinois Salukis Schedule
| Date | Time (ET) | Opponent | Result | Record |
| 09/06/2008 | 07:00 PM | Hampton | W, 37-31 | 1-0-0 |
| 09/13/2008 | 12:00 PM | at Northwestern | L, 33-7 | 1-1-0 |
| 09/27/2008 | 07:00 PM | Northern Iowa | W, 27-24 | 2-1-0 |
| 10/04/2008 | 02:00 PM | at North Dakota St | L, 35-27 | 2-2-0 |
| 10/11/2008 | 02:30 PM | Indiana State | W, 60-7 | 3-2-0 |
| 10/18/2008 | 04:00 PM | at Youngstown St | W, 33-0 | 4-2-0 |
| 10/25/2008 | 02:30 PM | at Missouri State | W, 23-17 | 5-2-0 |
| 11/01/2008 | 03:00 PM | North Dakota | W, 40-21 | 6-2-0 |
| 11/08/2008 | 03:00 PM | Western Ill | W, 24-14 | 7-2-0 |
| 11/15/2008 | 03:00 PM | South Dakota St | W, 38-35 | 8-2-0 |
| 11/22/2008 | 02:30 PM | at Illinois State | W, 17-10 | 9-2-0 |
| 11/29/2008 | 02:00 PM | New Hampshire | L, 29-20 | 9-3-0 |
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