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2008 S-M-U Mustangs Schedule
| Date | Time (ET) | Opponent | Result | Record |
| 08/29/2008 | 08:00 PM | at Rice | L, 56-27 | 0-1-0 |
| 09/06/2008 | 08:00 PM | Texas State | W, 47-36 | 1-1-0 |
| 09/13/2008 | 07:00 PM | at Texas Tech | L, 43-7 | 1-2-0 |
| 09/20/2008 | 08:00 PM | T-C-U | L, 48-7 | 1-3-0 |
| 09/25/2008 | 08:00 PM | at Tulane | L, 34-27 | 1-4-0 |
| 10/04/2008 | 03:30 PM | at U-C-F | L, 31-17 | 1-5-0 |
| 10/11/2008 | 08:00 PM | Tulsa | L, 37-31 | 1-6-0 |
| 10/18/2008 | 08:00 PM | Houston | L, 44-38 | 1-7-0 |
| 10/25/2008 | 03:30 PM | at Navy | L, 34-7 | 1-8-0 |
| 11/08/2008 | 03:00 PM | Memphis | L, 31-26 | 1-9-0 |
| 11/15/2008 | 09:05 PM | at Texas-El Paso | L, 36-10 | 1-10-0 |
| 11/29/2008 | 03:00 PM | Southern Miss | L, 28-12 | 1-11-0 |
