Indianapolis, IN -- (Sports Network) - Indianapolis Colts wide receiver Reggie Wayne and defensive end Dwight Freeney are both active for Sunday's game against the San Francisco 49ers.

Wayne tweaked his groin in last weekend's rout of the Rams, and Freeney had been dealing with a knee injury. Both practiced on Friday after being held out on Wednesday and Thursday.

Running back Donald Brown is out for the contest with a sprained shoulder, as is defensive back Marlin Jackson with a knee injury.

Other inactives include kicker Adam Vinatieri, offensive tackle Tony Ugoh and wide receiver Anthony Gonzalez.